ALS is a fatal motor neuron disease that has no cure and is estimated to affect hundreds of thousands of people worldwide. Why is a cure, or even a meaningful treatment, so elusive? We talk with data engineer, scientist, and rare disease advocate Danielle Boyce at ALS TDI about her work helping us all better understand this terrible illness. While the topic is grim, Danielle provides a lot of hope -- as well as inspiration to all of us to get involved in solving problems through data.

Dr. Steven Novella, clinical neurologist and host of The Skeptics' Guide to the Universe podcast joins us to share how he collects and analyzes data when he works with patients (there is so much more going on than I realized!) as well as how AI can hopefully improve the practice of medicine if we get it right. It's a longer episode than usual, but I hope you'll agree it's well worth it.

Science journalist and athlete Christie Aschwanden takes us inside the not-so-scientific world of the fitness and health data that's tracked by various apps we probably own and/or are tempted to buy, and she helps us more carefully discern what's actually useful to follow and what we're better off ignoring. Plus -- an existentially (and scientifically!) important discussion about the power of uncertainty (and why it doesn't have to feel bad)